diff --git a/server.go b/server.go
index eb780ac68..bcc8de6b2 100644
--- a/server.go
+++ b/server.go
@@ -141,6 +141,9 @@ func listen(conn net.PacketConn, tlsConf *tls.Config, config *Config) (*server,
 	if tlsConf == nil || len(tlsConf.Certificates) == 0 {
 		return nil, errors.New("quic: Certificates not set in tls.Config")
 	}
+	if len(tlsConf.NextProtos) == 0 {
+		return nil, errors.New("quic: NextProtos not set in tls.Config")
+	}
 	config = populateServerConfig(config)
 	for _, v := range config.Versions {
 		if !protocol.IsValidVersion(v) {
diff --git a/server_test.go b/server_test.go
index 00c0c78df..a8a26da59 100644
--- a/server_test.go
+++ b/server_test.go
@@ -42,6 +42,7 @@ var _ = Describe("Server", func() {
 		conn = newMockPacketConn()
 		conn.addr = &net.UDPAddr{}
 		tlsConf = testdata.GetTLSConfig()
+		tlsConf.NextProtos = []string{"proto1"}
 	})
 
 	It("errors when no tls.Config is given", func() {
@@ -56,6 +57,13 @@ var _ = Describe("Server", func() {
 		Expect(err.Error()).To(ContainSubstring("quic: Certificates not set in tls.Config"))
 	})
 
+	It("errors when NextProtos is not set in the tls.Config", func() {
+		tlsConf.NextProtos = nil
+		_, err := ListenAddr("localhost:0", tlsConf, nil)
+		Expect(err).To(HaveOccurred())
+		Expect(err.Error()).To(ContainSubstring("quic: NextProtos not set in tls.Config"))
+	})
+
 	It("errors when the Config contains an invalid version", func() {
 		version := protocol.VersionNumber(0x1234)
 		_, err := Listen(nil, tlsConf, &Config{Versions: []protocol.VersionNumber{version}})